QUANTUM_BIOPHYSICS

Prof. Antonio Bianconi

Born: Rome, 19 dec 1944

1969 Doctor degree in Physics at University of Rome

1970-1972 Euratom-ENEA Laboratory at Frascati Italy 1969-1972, researcher

1973-1975 Camerino University, Italy, Assistant Professor; and research associate at Laboratori Nazionali di Frascati, Frascati, Italy

1976-1977 Stanford University, SSRL, visiting professor and research associate Xerox Palo Alto Research Center, Palo Alto California

1978-1979 Camerino University, Italy, Assistant Professor

1980-1985 Rome University, Associate Professor of Experimental Physics

1986-1991 L'Aquila University, Italy, Professor of Medical Physics

1987- Visiting professor Tsukuba, Photon factory, Japan

1992 -Visiting Professor, Paris VII University, France

1993-today Sapienza University of Rome, Italy, Professor of Biophysics

 

His teachers have been: Gaetano Fichera, Gilberto Bernardini, Edoardo Amaldi, Bruno Tusheck, Giorgio Careri; he has worked and discussed with Ugo Fano, Paolo Fasella, Fred Brown, Seb Doniach, Britton Chance, Maurizio Brunori, Max Perutz, John Pendry, Alex K. Müller, Hans Frauefelder et al.

 

Number of publications in interantional journals with referees: 325 from 1969-today

Quantitative report from ISI Web of Science from 1991-today neglecting publications in the 1969-1991 period:

Publications, 286

Sum of citations, 4060

Citations per item, 14.20

H-index, 33

and

H-index, 40 including the papers published in the 1969-1991 period from google scholar.

 

 

He has been working in the field of biophysics since 1977 starting with the first applications of XANES (x-ray absorption near edge structure), named by him, using synchrotron radiation to the determination of the local structure of active sites of metalloproteins in solution.

He has contributed to several topics:

XANES of metal ions in biological membranes

XANES of calcium binding proteins: calmodulin, S100, troponin-C, parvalbumin

Active site structure of hemoglobin, myoglobin,

Ligand binding angle in emoproteins in solution and crystal

Polarized X-ray absorption of proteins

Local Fe structure modulation in the rransition between T-R conformations in hemoglobin

Effect of allosteric effectors in hemoglobin conformations

Cu K.edge XANES investigations of Hemocyanins

Structure-function relationship in the serotransferrin

Determination of the first intemediate state of CO in photodissociated carbonmonoxy myoglobin

Modulation of active sites in mutant myoglobin

The site structure modulation and function of tyrosinase in solution

The conformations landscape of the active site in myoglobin in the denaturation process

The introduction of TDXAS temperature dependent x-ray absorption spectroscopy for determination of the conformation landscape of carbonmonoxymyoglobin

The possible role of Feshbach resonances in biomolecular association and dissociation processes for evading quantum decoherence in living matter.

 

 

Selected pubblications in Biophysics

 

[1]                 The Emergence of Life in the Universe at the Epoch of Dark Energy Domination Nicola Poccia, Alessandro Ricci, Antonio Bianconi, Journal of Cosmology, 5, 875-882, (2010 ).

 

[2]                 A Possible Mechanism for Evading Temperature Quantum Decoherence in Living Matter by Feshbach Resonance Nicola Poccia, Alessandro Ricci, Davide Innocenti and Antonio Bianconi Int. J. Mol. Sci. 2009, 10(5), 2084-2106; doi:10.3390/ijms10052084 (special issue on the origin of life)". http://www.mdpi.com/1422-0067/10/5/2084

 

[3]                 TDXAS study of the conformational landscape of MbCO. A. Bianconi, F. Natali, M. L. Alosi, S. Grande, A. Lanzara, N. L. Saini, and M. Brunelli, Journal of synchrotron radiation 6, 389 (1999), ISSN 0909-0495, URL http://dx.doi.org/10.1107/S0909049598017063.

 

[4]                 Light induced states in MbCO denatured with guanidine hydrochloride. F. Natali, L. Moretti, F. Boffi, A. Bianconi, S. Della Longa, and A. Congiu Castellano, European biophysics journal : EBJ 27, 1 (1998), ISSN 0175-7571, URL http://view.ncbi.nlm.nih.gov/pubmed/9463885.

 

[5]                 Spin-resolved X-ray absorption near edge structure (XANES) simulation of metmyoglobin. S. Della Longa, M. Girasole, A. Congiu Castellano, A. Bianconi, A. P. Kovtun, and A. V. Soldatov, European Biophysics Journal 27, 541 (1998), ISSN 0175-7571, URL http://dx.doi.org/10.1007/s002490050164.

 

[6]                 Aluminum site structure in serum transferrin and lactoferrin revealed by synchrotron radiation X-ray spectroscopy. A. Congiu-Castellano, F. Boffi, S. Della Longa, A. Giovannelli, M. Girasole, F. Natali, M. Pompa, A. Soldatov, and A. Bianconi, Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 10, 363 (1997), ISSN 0966-0844, URL http://view.ncbi.nlm.nih.gov/pubmed/9353887.

 

[7]    The dinuclear copper site structure of Agaricus bisporus tyrosinase in solution probed by X-ray absorption spectroscopy. S. Della Longa, I. Ascone, A. Bianconi, A. Bonfigli, A. Congiu-Castellano, O. Zarivi, and M. Miranda, The Journal of biological chemistry 271, 21025 (1996), ISSN 0021-9258, URL http://dx.doi.org/10.1074/jbc.271.35.21025.

 

 

[8]                      Iron site structure of two irreversible hemichromes from human hemoglobin, untreated and oxidized to sulfoxide at MetD6(55)beta. S. Della Longa, G. Amiconi, O. Artan Salah, I. Ascone, M. Barteri, A. Bertollini, A. Bianconi, and A. Congiu Castellano, Biochimica et biophysica acta 1294, 72 (1996), ISSN 0006-3002, URL http://view.ncbi.nlm.nih.gov/pubmed/8639716

 

[9]                      Conformational states of hemoproteins by XANES: The mutant VR myoglobin S. Della-Longa, A. Bianconi, A. Brancaccio, M. Brunori, A. Congiu-Castellano, F. Cutruzzolā, J. L. Hazemann, M. Missori, and C. Travaglini-Allocatelli, Physica B: Condensed Matter 208-209, 743 (1995), ISSN 09214526, URL http://dx.doi.org/10.1016/0921-4526(94)01020-2.

 

[10]                Intermediate states in ligand photodissociation of carboxymyoglobin studies by dispersive X-ray absorption D. Della Longa S, I. Ascone, A. Fontaine, A. Congiu Castellano, and A. Bianconi, European biophysics journal : EBJ 23, 361 (1994), ISSN 0175-7571, URL http://view.ncbi.nlm.nih.gov/pubmed/7835320.

 

[11]                Structure-function relationship in the serotransferrin: the role of the pH on the conformational change and the metal ions release. A. Congiu Castellano, M. Barteri, M. Castagnola, A. Bianconi, E. Borghi, and S. Della Longa, Biochemical and biophysical research communications 198, 646 (1994), ISSN 0006-291X, URL http://view.ncbi.nlm.nih.gov/pubmed/8297375.

 

[12]                An x-ray absorption near edge structure spectroscopy study of metal coordination in Co(II)-substituted Carcinus maenas hemocyanin. S. Della Longa, A. Bianconi, L. Palladino, B. Simonelli, A. Congiu Castellano, E. Borghi, M. Barteri, M. Beltramini, G. P. Rocco, and B. Salvato, Biophysical journal 65, 2680 (1993), ISSN 0006-3495, URL http://dx.doi.org/10.1016/S0006-3495(93)81330-4.

 

[13]                Hemoglobins XAS Spectroscopy S. Pin, B. Alpert, A. Congiu Castellano, S. Della Longa, and A. Bianconi in Hemoglobins of the series Methods in Enzymology Part C Biophysical Methods edited by J. Everse, Kim D. Vandegriff, R. M. Winslow Academic Press, inc. San Diego California 1994 vol. 232 pag. 266-292 ISBN-13: 978-0121821333 http://www.amazon.com/Hemoglobins-Part-Biophysical-Methods-Enzymology/dp/0121821331

 

[14]                X-ray small angle scattering of the human transferrin protein aggregates. A fractal study. A. Congiu-Castellano, M. Barteri, A. Bianconi, E. Borghi, L. Cassiano, M. Castagnola, and S. Dellalonga, Biophysical journal 64, 520 (1993), ISSN 0006-3495, URL http://dx.doi.org/10.1016/S0006-3495(93)81394-8.

 

[15]                Influence of allosteric effectors on the heme conformation of dromedary ferrous nitrosylhemoglobin detected by XANES spectroscopy. A. Congiu Castellano, S. Della Longa, A. Bianconi, M. Barteri, E. Burattini, P. Ascenzi, M. Coletta, R. Santucci, and G. Amiconi, Biochimica et biophysica acta 1080, 119 (1991), ISSN 0006-3002, URL http://view.ncbi.nlm.nih.gov/pubmed/1932085.

 

[16]                Heterogeneity of the isolated subunits of the fetal and adult human hemoglobin in solution, detected by XANES spectroscopy. A. Congiu Castellano, M. Castagnola, E. Burattini, M. Dell'Ariccia, S. Della Longa, A. Giovannelli, P. J. Durham, and A. Bianconi, Biochimica et biophysica acta 996, 240 (1989), ISSN 0006-3002, URL http://view.ncbi.nlm.nih.gov/pubmed/2473782.

 

[17]                Influence of globin structure on the heme in dromedary carbonmonoxyhemoglobin. G. Amiconi, R. Santucci, M. Coletta, A. C. Castellano, A. Giovannelli, M. Dell'Ariccia, S. Della Longa, M. Barteri, E. Burattini, and A. Bianconi, Biochemistry 28, 8547 (1989), ISSN 0006-2960, URL http://view.ncbi.nlm.nih.gov/pubmed/2605205.

 

 

[18]                Linear Fe-C-O configuration in carbonyl 1-methylimidazole iron(II) porphyrin detected by XANES in dispersive mode. I. Ascone, A. Bianconi, E. Dartyge, S. Della Longa, A. Fontaine, and M. Momenteau, Biochimica et biophysica acta 915, 168 (1987), ISSN 0006-3002, URL http://view.ncbi.nlm.nih.gov/pubmed/3651469.

 

[19]                Oxygen bonding in human hemoglobin and its isolated subunits: a XANES study. A. Congiu-Castellano, A. Bianconi, M. Dell'Ariccia, S. Della Longa, A. Giovannelli, E. Burattini, and M. Castagnola, Biochemical and biophysical research communications 147, 31 (1987), ISSN 0006-291X, URL http://view.ncbi.nlm.nih.gov/pubmed/2443133.

 

[20]                Local Fe site structure in the tense-to-relaxed transition in carp deoxyhemoglobin: a XANES (x-ray absorption near edge structure) study. A. Bianconi, A. Congiu-Castellano, M. Dell'Ariccia, A. Giovannelli, S. Morante, E. Burattini, and P. J. Durham, Proceedings of the National Academy of Sciences of the United States of America 83, 7736 (1986), ISSN 0027-8424, URL http://view.ncbi.nlm.nih.gov/pubmed/3463997.

 

[21]                The CO bond angle of carboxymyoglobin determined by angular-resolved XANES spectroscopy A. Bianconi, A. Congiu-Castellano, P. J. Durham, S. S. Hasnain, and S. Phillips, Nature 318, 685 (1985), ISSN 0028-0836, URL http://view.ncbi.nlm.nih.gov/pubmed/4079982.

 

[22]                 Increase of the Fe effective charge in hemoproteins during oxygenation process. A. Bianconi, A. Congiu-Castellano, M. Dell'Ariccia, A. Giovannelli, E. Burattini, and P. J. Durham, Biochemical and biophysical research communications 131, 98 (1985), ISSN 0006-291X, URL http://view.ncbi.nlm.nih.gov/pubmed/4038310.

 

[23]                 Constraints of T conformation of carp azide hemoglobin on Fe site structure. A. Bianconi, A. Congiu-Castellano, M. L'Ariccia, A. Giovannelli, and S. Morante, FEBS letters 191, 241 (1985), ISSN 0014-5793.

 

[24]                Changes in Fe site structure from fetal to adult hemoglobin probed by XANES. A. Bianconi, A. Congiu-Castellano, M. Dell'Ariccia, A. Giovannelli, E. Burattini, M. Castagnola, and P. J. Durham, Biochimica et biophysica acta 831, 120 (1985), ISSN 0006-3002, URL http://view.ncbi.nlm.nih.gov/pubmed/2412587.

 

[25]                Determination of CO and CN bond angles by X-ray absorption edge structure in chelated protoheme in solution A. Bianconi A. Congiu-Castellano, M. Dell'ariccia, A. Giovannelli, E. Burattini, P.J. Durham, G.M. Giacometti, S. Morante Biochimica et Biophysica Acta 831, 114-119 (1985)

 

[26]                Increase of the Fe effective charge in hemoproteins during oxygenation process A. Bianconi, A. Congiu-Castellano, M. Dell'Ariccia, A. Giovannelli, E. Burattini, and P. J. Durham, Biochemical and biophysical research communications 131, 98 (1985), ISSN 0006-291X, URL http://view.ncbi.nlm.nih.gov/pubmed/4038310.

 

 

[27]                XANES study of iron displacement in the haem of myoglobin. A. Bianconi, A. Congiu-Castellano, M. Dell'Ariccia, A. Giovannelli, P. J. Durham, E. Burattini, and M. Barteri, FEBS letters 178, 165 (1984), ISSN 0014-5793, URL http://view.ncbi.nlm.nih.gov/pubmed/6500058.

 

[28]                X ray absorption near edge structure (XANES) for CO, CN and deoxy hemoglobin: geometrical information P. Durham, A. Bianconi, A. Congiu-Castellano, A. Giovannelli, S. S. Hasnain, L. Incoccia, S. Morante, and J. B. Pendry, The EMBO journal 2, 1441 (1983), ISSN 0261-4189, URL http://view.ncbi.nlm.nih.gov/pubmed/11892793.

 

[29]                XANES Determination of calcium sites of troponin-C and parvalbumin A. Bianconi, A. Giovannelli, L. Castellani, S. Alema, P. Fasella, B. Oesch, and S. Mobilio, Journal of molecular biology 165, 125 (1983), ISSN 0022-2836, URL http://view.ncbi.nlm.nih.gov/pubmed/6842603.

 

[30]                X-ray absorption spectroscopy (EXAFS and XANES) a structural tool for calcium binding proteins: effect of Mg2+ on Ca2+ binding sites of troponin-C, S. Alemā, A. Bianconi, L. Castellani, and P. Fasella, Progress in clinical and biological research 102 Pt C, 47 (1982), ISSN 0361-7742, URL http://view.ncbi.nlm.nih.gov/pubmed/7167467.

 

[31]                X-ray absorption near edge structure determination of calcium sites of troponin C and parvalbumin. A. Bianconi, S. Alema, L. Castellani, P. Fasella, A. Giovannelli, S. Mobilio, and B. Oesch, Acta radiologica. Supplementum 365, 27 (1983), ISSN 0365-5954. URL http://view.ncbi.nlm.nih.gov/pubmed/6591728.

 

[32]                Determination of the Ca site structure in the S 100 protein by using synchrotron radiation. Bianconi, A., Biocca, S., L. Castellani, L., Fasella, P., Comin F. und Mobilio S., Ital. J. Biochem., 29 (1); 71–73, (1980)

 

[33]                Structure of the calcium binding sites in troponin-C and calmodulin studied by EXAFS A. Bianconi, B. Oesh, S. Alemā, L. Castellani, I. Davoli, P. Fasella and S. Mobilio in Cacium binding proteins: Structure and function edited by F. L. Siegel et al. Elsevier North Holland, Amsterdam, pag. 297 (1980)

 

[34]                Correlation of k-absorption edge and exafs spectra of human ferric transferrin with those model iron(iii) complexes L. Alagna, A. A. G. Tomlinson, A. Bianconi, and A. Desideri, Inorganica Chimica Acta 40, X72+ (1980), ISSN 00201693, URL http://dx.doi.org/10.1016/S0020-1693(00)92141-8.

 

[35]                 X-ray Ca K edge of Calcium-Adenosine triphosphate system and of simple calcium Compounds A. Bianconi, S. Doniach, and D. Lublin, Chemical Physics Letters 59, 121 (1978), ISSN 00092614, URL http://dx.doi.org/10.1016/0009-2614(78)85629-2.

 

[36]                 Biophysics and Synchrotron Radiation edited by A. Bianconi and A. Congiu Castellano, Springer Series in Biophysics vol. 2 Springer Verlag, Berlin 1987

 

[37]                 XANES of Condensed Systems by A. Bianconi, J. Garcia, and M. Benfatto in Synchrotron Radiation in Chemistry and Biology I (Topics in Current Chemistry Vol. 145) by E. Mandelkow pp. 29-67 (1988) Spriger Verlag, Berlin 1988

 

 

He has introduced new physical experimental methods and concepts:

XEOL: x-ray emission optical luminescence;

XANES: x-ray absorption near edge structure, due to multiple scattering resonances for detecting high order correlation function of the local structure in complex systems:

SUPERSTRIPES: heterostructures at atomic limit where the quantum mechansm for evading temperature decoherence effects appears by tuning the chemecal potential.

 

Moreover he has been working in:

Liquid helium film

Photon-surface plasmon wave transformation

Photoemission spectroscopy of complex disordered systems since 1975

Synchrotron radiation research since 1972

Core excitons in synchrotron radiation absorption spectroscopy

Shape resonances in synchrotron radiation absorption spectroscopy

Multiple scattering resonances in XANES of complex systems

Ions in solution.

Catalists

Surfaces and interfaces

Correlated electronic systems

Valence fluctuation systems

High temperature superconductors