Abstract
  A new technique for sampling complex molecular systems with
  many degrees of freedom is proposed. The technique termed Multiple
  Replica Repulsion (MRR) does not suffer from poor scaling with the
  number of degrees of freedom associated with common replica exchange
  procedures and does not require sampling at high temperatures. The
  algorithm involves creation of multiple copies (replicas) of the
  system, which interact with one another through a repulsive
  potential that can be applied to the system as a whole or to a
  portion of it. The proposed scheme prevents oversampling of the most
  populated states and provides accurate descriptions of
  conformational perturbations typically associated with sampling
  ground state energy wells.